porx

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PorX/PorY is a two-component system (TCS) of Porphyromonas gingivalis that governs transcription of numerous genes including those encoding a type IX secretion system (T9SS) for gingipain secretion and heme accumulation. Here, an in vitro analysis ...

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The PorX/PorY system responds to hemin and confers resistance to H 2 O 2.A, 33277 wild-type strain (WT) and ΔporX mutant (YS19181) with or without complementation plasmid p-porX (pT-COW-P PGN_1016-porX) were grown in BHI medium supplemented with indicated amounts of hemin for indicated times. Data correspond to three independent assays ...

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Response regulator PorX coordinates oligonucleotide signalling and gene ...

PorX is a highly conserved protein that regulates the transcription of essential T9SS components and additionally mediates the function of T9SS via direct interaction with PorL, the rotary motor protein of the T9SS.

Structure-function analysis of PorXFj, the PorX homolog from ...

The Type-IX secretion system (T9SS) is a nanomachinery utilized by bacterial pathogens to facilitate infection. The system is regulated by a signaling cascade serving as its activation switch. A pivotal member in this cascade, the response regulator protein PorX, represents a promising drug target to prevent the secretion of virulence factors.